During brain development signaling proteins guide traveling neurons and their axons. These proteins do so by binding the receptor on the cell membrane of the neuron. For a long time it was thought that when two different proteins are close to the receptor they compete for binding. However, we found that instead of competing for binding, two different proteins can both bind the receptor at the same time. When this binding occurs the receptor is turned off, meaning that the neuron turns insensitive to signals. Because we now better understand this mechanism we might be able to use this knowledge in the future to answer disease-related questions.
Our teaching mission is to raise the next generation scientists and clinicians with state-of-the-art knowledge, technical expertise and vision in the field of neuroscience. As a part of this effort, we teach in several Bachelor courses, coordinate the Neuroscience and Cognition master program of the Utrecht University and offer doctoral and postdoctoral training.
Together with other astrocyte researchers, Translational Neuroscience researcher Elly Hol wrote this highly needed paper for the field. This paper will be an important overview for all interested in reactive astrocytes in brain diseases.
We welcome open applications from PhD candidates and postdocs.