Studying synapses in specific neural circuits

In recent years the combination of brain slice electrophysiological recordings of neurons in response to optogenetic stimulation of their input, has become an indispensable staple to probe the function of neural circuits. The large amounts of distinct metrics that one can obtain this way are both informative but also daunting …

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Renata Vieira de Sá finalises her PhD on ALS

Another successful PhD on ALS! On Thursday 20th of October Renata Vieira de Sa defended her PhD thesis “Repeat expansions in Amyotrophic lateral sclerosis  (ALS). Lessons from patient-derived models” at the Academiegebouw of Utrecht University. In her PhD thesis, Renata studied the contribution of C9orf72 and Ataxin2 repeat expansion to …

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PhD defense of Christiaan Huffels

On Tuesday October 18, Christiaan Huffels successfully defended his PhD thesis, titled “Tracing the signals: Unravelling neuron-glia interactions in Alzheimer’s disease”, at the Academiegebouw of Utrecht University. In his thesis, Christiaan examined the role of astrocytes and microglia in the early development of Alzheimer’s disease using a multidisciplinary approach, combining …

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GliaNed meeting 2022

Big success with the annual GliaNed meeting! The main goals of this informal meeting are to stimulate interaction between glia researchers in The Netherlands and to exchange knowledge. Elly Hol (translational neuroscience, UMCU) and Wia Baron (UMCG) put together a great program and were thrilled to have Prof. Inge Huitinga …

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Inauguration of Elly Hol as a KNAW member

We proudly celebrate the inauguration of prof. Elly Hol of our Translational Neuroscience department as a Royal Netherlands Academy of Arts and Sciences (KNAW) member 🎊! She is one of the 22 new members who were at the historic Trippenhuis this Monday. This is a great honor given to a …

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Leptin targets spatially diverse neurons

Leptin is a hormone that is secreted by fat and signals the need to stop eating and increase energy expenditure via leptin receptors (LepR). Various hunger and reward centers in the brain contain different LepR expressing neurons. The primary leptin center is the well-studied arcuate nucleus. Other hypothalamic nuclei are …

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Characterising social stress responsive ventral tegmental area neurons

In this study published at Frontiers in Behavioral Neuroscience, Ioannis Koutlas and colleagues of the Meye lab, use the expression of immediate-early genes to characterize social-stress activated neuronal subsets in the ventral tegmental area. They show that cells of different molecular identities (dopaminergic, GABAergic, glutamatergic and combinatorial neurons) that are …

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Cellular diversity of the developing mouse Habenula

The habenula (Hb) plays a key role in processing reward information and mediating aversive responses to negative stimuli. In the recent issue of Cell Reports, Lieke van de Haar and colleagues have revealed how the cellular diversity of the mouse habenula is formed during development. In the work title “Cellular …

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