GliaNed meeting 2022
Big success with the annual GliaNed meeting! The main goals of this informal meeting are to stimulate interaction between glia researchers in The Netherlands and to exchange knowledge. Elly Hol (translational neuroscience, UMCU) and Wia Baron (UMCG) put together a great program and were thrilled to have Prof. Inge Huitinga to open the show with her keynote lecture on ‘The role of microglia in MS and major depression’.
The meeting got additional contribution from our department. Carla Gomes da Silva presented her work on how oligodendrocyte precursors regulate cortical networks during mammalian development. Werner Dykstra explained how he studies the role of the astrocyte cytoskeletion in brain organoids. Several other researchers throughout the Netherlands have presented their latest research.
“It is very impressive how glia is involved practically in every brain process and disease you can imagine. GliaNed is providing an essential platform to bring researchers of this rapidly growing field together” Onur Basak
We hope to see the community at the next GliaNed meeting in Groningen.
Inauguration of Elly Hol as a KNAW member
We proudly celebrate the inauguration of prof. Elly Hol of our Translational Neuroscience department as a Royal Netherlands Academy of Arts and Sciences (KNAW) member 🎊! She is one of the 22 new members who were at the historic Trippenhuis this Monday. This is a great honor given to a select group of scientists in the Netherlands
Elly Hol external link is Professor of Gliabiology of Brain Diseases and one of the heads of the Translational Neuroscience Department at the UMC Utrecht Brain Centre. Tained as a medical biologist with a specialisation in molecular neurobiology, she obtained her PhD in Utrecht. Next, she worked at the Max-Planck-Institute for Psychiatry in Martinsried with a Max-Planck Fellowship to. From 2013 onwards, Elly has worked as a principal investigator. In 2015, whe was appointed Professor of Gliabiology of Brain Diseases at the Utrecht University. She is a member of the Academia Europaea, chair of the scientific advisory board of Parkinson Netherlands, chair of GliaNed, programme leader of the Neuroscience master’s and PhD programme at Utrecht University Graduate School of Life Sciences, and education manager at the Brain Division of UMC Utrecht. Her inauguration was the results of years of contribution to the establishment of glia biology.
“Elly Hol belongs to the still small but growing group of neuroscientists who focus on the biology of glia. These are non-neuronal cells that play a crucial role in keeping our brain healthy. They act as stem cells and immune system, but can also derail. Hol has published a number of highly cited articles, in which she uncovers a correlation between certain proteins in the human brain and glial cells that play a role in the development of brain tumors and diseases such as Alzheimer’s and epilepsy. Hol is an important source of inspiration for young researchers, including through the national Glia network she leads and through personal mentorships for young female researchers.” KNAW
You can find more information on her research at our website and her lab page. More information on the inauguration is available on the Utrecht University and KNAW websites.
ENW-M-2 grant for Heidi Lesscher and Frank Meye on risky play and stress resilience
New ENW-M-2 grant for our researchers! Recently the NWO Domain Board Science approved twenty-six grant applications in the Open Competition Domain Science-M programme. One of these grants was awarded to Heidi Lesscher (PHS, DWM) and Frank Meye (Translational Neuroscience, UMC Utrecht) to study if early life play opportunity, and in particular ‘risky’ play, promotes the development of cognitive control and stress resilience in later life. In this project, rats experiencing different degrees of play during early life will be compared for their degree of cognitive control under stress. Expectations are that enhanced opportunities for risky social play in early life enhance stress resilience in later life. We will also address the neurobiological effects of social play on cognitive control networks. Understanding how play shapes stress resilience is important for the prevention of mental health problems. Stay tuned for positions opening up related to this project.
“Very excited to team up with Heidi Lesscher to unravel if early life risky play opportunities alter neural networks of cognitive control to confer stress resilience in later life” Frank Meye
This research will in part be carried out at our Translational Neuroscience Department, as part of the UMC Utrecht Brain Center.
Leptin targets spatially diverse neurons
Leptin is a hormone that is secreted by fat and signals the need to stop eating and increase energy expenditure via leptin receptors (LepR). Various hunger and reward centers in the brain contain different LepR expressing neurons. The primary leptin center is the well-studied arcuate nucleus. Other hypothalamic nuclei are less abundant in leptin receptor but also essential in encoding leptin’s actions. The composition of these LepR neurons have not been well understood.
In their recently published paper in Science Reports, Nefeli Kakava and colleagues from the UMC Utrecht Brain Center explore the scarce LepR population in the lateral hypothalamus. This population is known for its effects on food intake and food reward, and may be defective in eating disorders. The authors successfully capture the transcriptome of these neurons using TRAP-Seq. Exploration of their molecular profile confirms the expression of diverse neuropeptides and receptors. Microscopy analysis reveal their diverse spatial expression patterns. Moreover, they unravel new markers that could have significant role in energy balance. They also explore what is the transcriptional response of these neurons to energy deficit.
“I am excited that we have successfully managed to capture RNA from this very rare albeit significant population of leptin responsive cells and hope our findings inspire new research”
Nefeli obtained her PhD in 2020 as part of the Adan lab, where she developed viral vector tools to target and manipulate the activity of brain cells involved in food reward and energy balance. In collaboration with the Basak lab, she has profiled the hypothalamic LepR cells using TRAP-Seq and single cell genomics techniques.
Characterising social stress responsive ventral tegmental area neurons
In this study published at Frontiers in Behavioral Neuroscience, Ioannis Koutlas and colleagues of the Meye lab, use the expression of immediate-early genes to characterize social-stress activated neuronal subsets in the ventral tegmental area. They show that cells of different molecular identities (dopaminergic, GABAergic, glutamatergic and combinatorial neurons) that are dispersed throughout the entire VTA are activated by a social stress episode. Furthermore, they validate the use of targeted recombination in active populations (TRAP2) to capture this VTA stress-activated neuronal ensemble and make it tractable for further manipulations. Finally, the use of TRAP2 allowed them to look into intrinsic electrophysiological properties of these neurons and show that stress activated VTA cells are more excitable than neighbouring cells that were not activated by stress.
“I am very excited that this work is published. It gives insight on stress-encoding VTA neuronal populations and provides us with the tools to answer further exciting questions” – Ioannis