Studying synapses in specific neural circuits

In recent years the combination of brain slice electrophysiological recordings of neurons in response to optogenetic stimulation of their input, has become an indispensable staple to probe the function of neural circuits. The large amounts of distinct metrics that one can obtain this way are both informative but also daunting …

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Renata Vieira de Sá finalises her PhD on ALS

Another successful PhD on ALS! On Thursday 20th of October Renata Vieira de Sa defended her PhD thesis “Repeat expansions in Amyotrophic lateral sclerosis  (ALS). Lessons from patient-derived models” at the Academiegebouw of Utrecht University. In her PhD thesis, Renata studied the contribution of C9orf72 and Ataxin2 repeat expansion to …

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GliaNed meeting 2022

Big success with the annual GliaNed meeting! The main goals of this informal meeting are to stimulate interaction between glia researchers in The Netherlands and to exchange knowledge. Elly Hol (translational neuroscience, UMCU) and Wia Baron (UMCG) put together a great program and were thrilled to have Prof. Inge Huitinga …

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Leptin targets spatially diverse neurons

Leptin is a hormone that is secreted by fat and signals the need to stop eating and increase energy expenditure via leptin receptors (LepR). Various hunger and reward centers in the brain contain different LepR expressing neurons. The primary leptin center is the well-studied arcuate nucleus. Other hypothalamic nuclei are …

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Cellular diversity of the developing mouse Habenula

The habenula (Hb) plays a key role in processing reward information and mediating aversive responses to negative stimuli. In the recent issue of Cell Reports, Lieke van de Haar and colleagues have revealed how the cellular diversity of the mouse habenula is formed during development. In the work title “Cellular …

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PhD defence of Andreia Duarte and Lieke van de Haar

PhD defence is a special occasion celebrating not only the graduation of a student but also the society gaining a new highly trained specialist. Last week, Andreia Duarte and Lieke van de Haar of the Pasterkamp lab have defended their PhD thesis with two in-person PhD defences at the Academiegebouw …

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Single-cell profiling adult human neural stem cells

Neural stem cells (NSCs) of the subventricular zone (SVZ) remain mostly in a dormant state in the adult human brain after closure of the neurogenic period at birth. These dormant progenitors rarely proliferate or produce neurons. How an adult human NSC is maintained in this quiescent state and could be …

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Astrocyte function in early-stage Alzheimer’s disease on GLIA

Astrocytes are literally the star cells of our brains! PhD candidate Christiaan Huffels, from the group of Elly Hol, recently published a study on astrocyte function in early-stage Alzheimer’s disease in the scientific journal GLIA. Alzheimer’s Disease is the main form of dementia in the elderly, characterised by the accumulation …

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Two tenure track assistant professor positions (EXPIRED ON 28-02-2022)

We are recruiting young talent for two tenure track assistant professor positions! Tenure track assistant professor in cell and molecular neurobiology A tenure track assistant professor position in molecular and cellular neurobiology is now open for applications! We seek outstanding candidates with an excellent track record in cellular or mouse …

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