Dr. Onur Basak

Dr. Onur Basak
How does the diversity of the brain emerge? Can we define molecular basis for the functional diversity of our brain? Is there a molecular signature of time? These curiosity-driven questions have led my path, which started as a molecular biologist and to the fields of developmental neuroscience and adult somatic stem cells. I was fascinated by the world of single cell genomics, which my group employs to study the development and diversity of Brain's reward system.
mouse genetics, organoids, single cell genomics, neural stem cells

Tiziana Hey, MSc

Tiziana Hey, MSc
PhD student
Generating a single cell RNAseq/ChIC-seq reference atlas of the adult mouse VTA as part of the BRAINSCAPES consortium and determining how histone methylation contributes to the cellular heterogeneity and long term differences in perturbation within the reward system.
Single-cell omics, immunohistochemistry, Ventral Tegmental Area (VTA), cell/nuclei isolation from mouse brain.

Keith Garner

Keith Garner
Senior Research Technician
Assisting the group primarily with cell culture, molecular biology and genotyping. Master of modified lenti- and AAV viruses. His new hobby is the cell/nuclei sorting.

Recent papers

Basak lab

  1. Saglam-Metiner P, Yildirim E, Dincer C, Basak O, Yesil-Celiktas O. Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity. Mikrochim Acta. 2024 Jan 3;191(1):71. doi: 10.1007/s00604-023-06165-4. PMID: 38168828
  2. Kakava-Georgiadou N, Drkelic V, Garner KM, Luijendijk MCM, Basak O, Adan RAH. Molecular profile and response to energy deficit of leptin-receptor neurons in the lateral hypothalamus. Sci Rep. 2022 Aug 4;12(1):13374. doi: 10.1038/s41598-022-16492-w. PMID: 35927440; PMCID: PMC9352899
  3. van de Haar LL, Riga D, Boer JE, Garritsen O, Adolfs Y, Sieburgh TE, van Dijk RE, Watanabe K, van Kronenburg NCH, Broekhoven MH, Posthuma D, Meye FJ, Basak O, Pasterkamp RJ. Molecular signatures and cellular diversity during mouse habenula development. Cell Rep. 2022 Jul 5;40(1):111029. doi: 10.1016/j.celrep.2022.111029. Epub 2016 Dec 8. PMID: 35793630
  4. Schneider J, Weigel J, Wittmann MT, Svehla P, Ehrt S, Zheng F, Elmzzahi T, Karpf J, Paniagua-Herranz L, Basak O, Ekici A, Reis A, Alzheimer C, Ortega de la O F, Liebscher S, Beckervordersandforth R. Astrogenesis in the murine dentate gyrus is a life-long and dynamic process. EMBO J. 2022 Jun 1;41(11):e110409. doi: 10.15252/embj.2021110409. Epub 2022 Apr 22. PMID: 35451150
  5. Stenudd M, Sabelström H, Llorens-Bobadilla E, Zamboni M, Blom H, Brismar H, Zhang S, Basak O, Clevers H, Göritz C, Barnabé-Heider F, Frisén J. Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties. Cell Rep. 2022 Mar 1;38(9):110440. doi: 10.1016/j.celrep.2022.110440. PMID: 35235796
  6. Donega V, van der Geest AT, Sluijs JA, van Dijk RE, Wang CC, Basak O, Pasterkamp RJ, Hol EM. Single-cell profiling of human subventricular zone progenitors identifies SFRP1 as a target to re-activate progenitors. Nat Commun. 2022 Feb 24;13(1):1036. doi: 10.1038/s41467-022-28626-9. PMID: 35210419; PMCID: PMC8873234
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