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Translational Neuroscience

The research mission of the Department of Translational Neuroscience is to discover and delineate mechanisms and processes which are fundamental to the development of neural systems and to the control of behavior as well as to translate these to pathogenesis and disease models. We use cutting edge technology, disease models as well as computational tools to achieve these goals.

Our teaching mission is to raise the next generation scientists and clinicians with state-of-the-art knowledge, technical expertise and vision in the field of neuroscience. As a part of this effort, we teach in several Bachelor courses, coordinate the Neuroscience and Cognition master program of the Utrecht University and offer doctoral and postdoctoral training.

News

April 26, 2021 / News, Research paper

No need for competition

During brain development signaling proteins guide traveling neurons and their axons. These proteins do so by binding the receptor on the cell membrane of the neuron. For a long time it was thought that when two different proteins are close to the receptor they compete for binding. However, we found that instead of competing for binding, two different proteins can both bind the receptor at the same time. When this binding occurs the receptor is turned off, meaning that the neuron turns insensitive to signals. Because we now better understand this mechanism we might be able to use this knowledge in the future to answer disease-related questions.

https://www.cell.com/cell/fulltext/S0092-8674(21)00234-8

March 3, 2021 / News, Research paper

Reactive astrocyte nomenclature, definitions, and future directions

Together with other astrocyte researchers, Translational Neuroscience researcher Elly Hol wrote this highly needed paper for the field. This paper will be an important overview for all interested in reactive astrocytes in brain diseases.

https://www.nature.com/articles/s41593-020-00783-4

Vacancies

We are looking for new PhD candidates and postdocs.

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